反应详情

To a solution of 2.5 g of 2-(4-methoxy-3,5-dimethyl-phenyl)-5-methylsulfanyl-7-propoxy-oxazolo[5,4-d]pyrimidine in 50 ml of dichloromethane 0.70 ml of boron tribromide were added slowly at −20° C. After 1 h at −20° C. and 2 h at room temperature, the mixture was quenched by addition of a saturated aqueous sodium hydrogencarbonate solution while maintaining a temperature below 5° C. The phases were separated, and then the aqueous phase was extracted twice with dichloromethane. The combined organic phases were dried and concentrated in vacuo. 2.0 g of the title compound were obtained.

1. custom2 h at room temperature, the mixture was quenched by addition of a saturated aqueous sodium hydrogencarbonate solution
2. temperaturewhile maintaining a temperature below 5° C
3. customThe phases were separated
4. extractionthe aqueous phase was extracted twice with dichloromethane
5. customThe combined organic phases were dried
6. concentrationconcentrated in vacuo