HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 403482Generated: October 30, 2026
Diisobutylaluminum hydride → (E)-3-[4-(2-ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-phenyl]-prop-2-en-1-ol
https://huagongshe.com/reaction/403482
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | (E)-3-[4-(2-ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-phenyl]-acrylic acid methyl ester | HCID 68379176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-3-[4-(2-ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-phenyl]-prop-2-en-1-ol | HCID 68378973 | — |
Reaction Steps
(E)-3-[4-(2-Ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-phenyl]-acrylic acid methyl ester (4) (780 mg, 2.3 mmol), was dissolved in 23 ml dichloromethane and cooled to −78° C. A 1.2M solution of DIBAH in dichloromethane (5.8 ml, 7 mmol) was added dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08748435B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-9f7428c8bf324aa1bcb760fdeabc2fec |
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| Source note | uspto-grants-2014_06 |
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