反应详情

温度

0 °C

In a argon flushed dry 25 ml 2-neckoundbottomflask (S)-2-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (34) (0.6 g, 2.81 mmol) was dissolved in 10 ml of ether. A 1M solution of allylmagnesiumbromide in Et2O (3.66 ml, 3.66 mmol) was added dropwise at 0° C. The reaction mixture was stirred at 0° C. for 2 h. The mixture was quenched with NH4Cl solution and extracted with ether. The organic layer was washed with brine, dried over Na2 SO4 and evaporated. The crude product was purified by flash chromatography (silica gel, 20-30% EtOAc/cyclohexane) which furnished the product as white solid

1. customIn a argon flushed
2. customThe mixture was quenched with NH4Cl solution
3. extractionextracted with ether
4. washThe organic layer was washed with brine
5. customdried over Na2 SO4
6. customevaporated
7. customThe crude product was purified by flash chromatography (silica gel, 20-30% EtOAc/cyclohexane) which