4-t-Butylbenzenesulfonyl chloride → HCID 10196164, compound

HRID 403537Notes

Reaction equation

HRID 403537 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][C:14]([CH3:20])=[CH:15][CH:16]=3)[N:11]=[C:10]2[CH:21]([NH:23][CH3:24])[CH3:22])=[CH:5][CH:4]=1.[C:25]([C:29]1[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1)([CH3:28])([CH3:27])[CH3:26]>>[C:25]([C:29]1[CH:34]=[CH:33][C:32]([S:35]([N:23]([CH:21]([C:10]2[N:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)[C:18](=[O:19])[C:17]3[C:12](=[CH:13][C:14]([CH3:20])=[CH:15][CH:16]=3)[N:11]=2)[CH3:22])[CH3:24])(=[O:37])=[O:36])=[CH:31][CH:30]=1)([CH3:28])([CH3:26])[CH3:27]

Participants

3

Reactant 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 66689645HCID 66689645, compound

Product 1

HCID 10196164HCID 10196164, compound

Procedure

In a similar manner as described above in Paragraph A, 3-(4-methoxyphenyl)-7-methyl-2-(1-methylaminoethyl)-3H-quinazolin-4-one, as prepared above in Example 5, was condensed with 4-tert-butylbenzenesulfonyl chloride to yield 4-tert-butyl-N-{1-[3-(4-methoxyphenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methylbenzenesulfonamide; MS (ESI) 520 (MH+).

Workup

  1. customas prepared above in Example 5

Sources & evidence

ORD record
ord-f85a6ce11a2042f08fe74096e19746fa
Source dataset
uspto-grants-2014_06
Patent number
US08748440B2

Reaction notes

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