4-tert-Butylbenzoyl chloride → HCID 66689935, compound

HRID 403541Notes

Reaction equation

HRID 403541 reaction equation
FC1C=C[C:5]([N:8]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=[C:9]2[CH:19]([NH:21][CH3:22])[CH3:20])=CC=1.[C:23]([C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1)([CH3:26])([CH3:25])[CH3:24]>>[C:23]([C:27]1[CH:28]=[CH:29][C:30]([C:31]([N:21]([CH3:22])[CH:19]([C:9]2[N:8]([CH3:5])[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)[CH3:20])=[O:32])=[CH:34][CH:35]=1)([CH3:26])([CH3:24])[CH3:25]

Participants

3

Reactant 2

HCID 743724-tert-Butylbenzoyl chlorideHCID 23071326HCID 23071326, compound

Product 1

HCID 66689935HCID 66689935, compound

Procedure

In a similar manner as described above in Paragraph A, but replacing 3-(4-methoxyphenyl)-2-(1-methylaminoethyl)-3H-quinazolin-4-one with 3-(4-fluorophenyl)-2-(1-methylaminoethyl)-3H-quinazolin-4-one and 4-tert-butylbenzoyl chloride with the appropriate starting material, the following compounds were made:

Sources & evidence

ORD record
ord-b688af85f7db4c0fbc962c63a0af670d
Source dataset
uspto-grants-2014_06
Patent number
US08748440B2

Reaction notes

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