4-t-Butylbenzenesulfonyl chloride → HCID 66689746, compound

HRID 403546Notes

Reaction equation

HRID 403546 reaction equation
[CH3:1][N:2]([CH3:24])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]2[CH:20]([NH:22][CH3:23])[CH3:21])=[CH:5][CH:4]=1.[C:25]([C:29]1[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1)([CH3:28])([CH3:27])[CH3:26]>>[C:25]([C:29]1[CH:34]=[CH:33][C:32]([S:35]([N:22]([CH:20]([C:10]2[N:9]([C:6]3[CH:7]=[CH:8][C:3]([N:2]([CH3:1])[CH3:24])=[CH:4][CH:5]=3)[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH3:21])[CH3:23])(=[O:37])=[O:36])=[CH:31][CH:30]=1)([CH3:28])([CH3:26])[CH3:27]

Participants

3

Reactant 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 66689442HCID 66689442, compound

Product 1

HCID 66689746HCID 66689746, compound

Procedure

In a similar manner as described above in Example 7, 3-(4-dimethylamino-phenyl)-2-(1-methylaminoethyl)-3H-quinazolin-4-one, as prepared above in Paragraph L, was condensed with 4-tert-butylbenzenesulfonyl chloride to yield 4-tert-butyl-N-{1-[3-(4-dimethylamino-phenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methylbenzenesulfonamide; MS (ESI) 519 (MH+).

Workup

  1. customas prepared above in Paragraph L

Sources & evidence

ORD record
ord-1f1cf16957e3471d8280a790869c1275
Source dataset
uspto-grants-2014_06
Patent number
US08748440B2

Reaction notes

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