反应详情

1.95 g of potassium isocyanate in solution of 4 ml of water are added to a solution of 6.63 g of 1,1-dimethylethyl 4-{[4-(2,2-difluoroethoxy)-2-(methoxycarbonyl)phenyl]amino}piperidine-1-carboxylate obtained in stage 3.3 in 40 ml of AcOH. The mixture is stirred at AT for 12 h 00. It is extracted with AcOEt and the extract is washed with a saturated K2CO3 solution and then with water. It is dried over MgSO4, filtered and evaporated under reduced pressure to give 6.95 g of the expected product.

1. extractionIt is extracted with AcOEt
2. washthe extract is washed with a saturated K2CO3 solution
3. dry with materialIt is dried over MgSO4
4. filtrationfiltered
5. customevaporated under reduced pressure