Triphosgene → (S)-3-isocyanato-2,2-dimethyl-butane

Participants

Reaction Steps

To a solution of (S)-1,2,2-trimethylpropylamine (626 mg, 6.2 mmol) in methylene chloride (20 mL) and satd aq NaHCO3 (20 mL) was added triphosgene (607 mg, 2.05 mmol) at 0° C. The mixture was stirred for 15 min. The organic phase was separated, dried and concentrated to give (S)-3-isocyanato-2,2-dimethyl-butane (845 mg, 90%). 1H NMR (CDCl3): 0.90 (s, 9H), 1.21 (m, 3H), 3.31 (m, 1H).

Provenance & Evidence