Ethyl 6-bromohexanoate → 6-(6-Bromo-1,2,3,4-tetrahydro-carbazol-9-yl)-hexanoic acid ethyl ester

HRID 403647Notes

Reaction equation

HRID 403647 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][CH2:7][CH2:6][C:5]2=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22].C(OC(=O)C1C=CC(CN2C3C=CC=CC=3C3C2=CC=CC=3)=CC=1)C>>[CH2:24]([O:23][C:21](=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][N:11]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[C:4]2[C:12]1=[CH:13][CH:14]=[C:2]([Br:1])[CH:3]=2)[CH3:25]

Participants

4

Reactant 3

HCID 117544Ethyl 6-bromohexanoateHCID 2688776-Bromo-1,2,3,4-tetrahydrocarbazoleHCID 683803104-Carbazol-9-ylmethyl-benzoic acid ethyl ester

Product 1

HCID 668733756-(6-Bromo-1,2,3,4-tetrahydro-carbazol-9-yl)-hexanoic acid ethyl ester

Procedure

Compound 31 was prepared from 6-bromo-2,3,4,9-tetrahydro-1H-carbazole (30) (1.50 g, 6.00 mmol) and ethyl 6-bromohexanoate (1.34 g, 6.00 mmol) using the procedure described above for compound 28 as a solid (1.453 g).

Sources & evidence

ORD record
ord-0568796f785d420ca1a1a8db390bc53c
Source dataset
uspto-grants-2014_06
Patent number
US08748451B2

Reaction notes

Loading…