HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-4-(methylsulfonamido) styrylboronic acid → (E)-N-(4-(3-tert-butyl-5-(2,4-di-tert-butoxypyrimidin-5-yl)-2-methoxystyryl)phenyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-4-(methylsulfonamido) styrylboronic acid | HCID 57775250 | — |
| Reactant | 5-(3-Bromo-5-tert-butyl-4-methoxyphenyl)-2,4-di-tert-butoxy-pyrimidine | HCID 66833848 | — |
| Product | (E)-N-(4-(3-tert-butyl-5-(2,4-di-tert-butoxypyrimidin-5-yl)-2-methoxystyryl)phenyl)methanesulfonamide | HCID 66833874 | — |
Reaction Steps
The product from Example 2 Part A (55.9 mg, 0.12 mmol) and (E)-4-(methylsulfonamido) styrylboronic acid (28.9 mg, 0.120 mmol) were reacted in the same manner as Example 2 Step B. The crude product was purified by silica gel flash chromatography eluting with ethyl acetate/hexane (5% to 25%) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748443B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-180e3b4b26fd44c9a28bcf072b9cd136 |
| Source note | uspto-grants-2014_06 |