反应详情

To a solution of 3-tert-butyl-5-iodo-4-methoxyaniline (458 mg, 1.5 mmol) in dioxane (5 mL) was added ethyl isocyanatoacetate (0.168 mL, 1.500 mmol) dropwise producing a solution that was stirred at room temperature for 16 hours. The reaction mixture was concentrated and the product was triturated in 9:1 hexane/ethyl acetate. The resulting solid was collected by filtration and dried to give the title compound.

1. customdropwise producing a solution that
2. concentrationThe reaction mixture was concentrated
3. customthe product was triturated in 9:1 hexane/ethyl acetate
4. filtrationThe resulting solid was collected by filtration
5. customdried