Chloroacetyl isocyanate → HCID 66700059, compound

HRID 403674Notes

Reaction equation

HRID 403674 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:9]=[C:10]([I:14])[C:11]=1[O:12][CH3:13])[NH2:8])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:16][C:17]([N:19]=[C:20]=[O:21])=[O:18]>>[C:1]([C:5]1[CH:6]=[C:7]([N:8]2[CH2:16][C:17](=[O:18])[NH:19][C:20]2=[O:21])[CH:9]=[C:10]([I:14])[C:11]=1[O:12][CH3:13])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 78209Chloroacetyl isocyanateHCID 57419443HCID 57419443, compound

Product 1

HCID 66700059HCID 66700059, compound

Procedure

3-tert-Butyl-5-iodo-4-methoxyaniline (915 mg, 3.0 mmol) and chloroacetyl isocyanate (0.256 mL, 3.00 mmol) were reacted in the same manner as Example 14 Part A to give crude product which was purified on an Isco 40 g silica cartridge eluting with methanol/dichloromethane (0% to 5%) to give the title compound.

Workup

  1. customto give crude product which
  2. customwas purified on an Isco 40 g silica cartridge
  3. washeluting with methanol/dichloromethane (0% to 5%)

Sources & evidence

ORD record
ord-3ada6b1746e848f4bef413e48161701f
Source dataset
uspto-grants-2014_06
Patent number
US08748443B2

Reaction notes

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