2,4-Difluorophenyl isocyanate → (S)-Methyl 2-(6-(4-(3-(2,4-difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Participants

Reaction Steps

The compound of example 9 was prepared analogous to compound of example 7 by reaction of compound of example 6 with 2,4-difluorophenyl isocyanate. The compound of example 9 was used directly without isolation for the preparation of compound of example 10.

Provenance & Evidence