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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 403702Generated: October 27, 2026

3-Fluorophenyl isocyanate → (S)-Methyl 2-(6-(4-(3-(3-fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

https://huagongshe.com/reaction/403702

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluorophenyl isocyanateHCID 123064—
Reactant(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441—
Product(S)-Methyl 2-(6-(4-(3-(3-fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731442—

Reaction Steps

The compound of example 13 was prepared analogous to compound of example 7 by reaction of compound of example 6 with 3-fluorophenyl isocyanate. The compound of example 13 was used directly without isolation for the preparation of compound of example 14.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-02dae67ab0964510adac74c5de9f1583
Source noteuspto-grants-2014_06