HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → (S)-2-(6-(4-(3-(2,6-Difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid | HCID 53303121 | — |
| Reactant | (S)-Methyl 2-(6-(4-(3-(2,6-difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731443 | — |
| Product | (S)-2-(6-(4-(3-(2,6-Difluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid | HCID 67306695 | 90% |
Reaction Steps
The compound of example 20 was prepared analogous to compound of example 8 by hydrolysis of compound of example 19.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-04b2ae675e3e412f93e716d77829223c |
| Source note | uspto-grants-2014_06 |