(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → (S)-3-Methyl-2-(1-oxo-6-(4-(3-m-tolylureido)phenyl)isoindolin-2-yl)butanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid	HCID 53303121	—
Reactant	(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(3-m-tolylureido)phenyl)isoindolin-2-yl)butanoate	HCID 131731444	—
Product	(S)-3-Methyl-2-(1-oxo-6-(4-(3-m-tolylureido)phenyl)isoindolin-2-yl)butanoic acid	HCID 67307023	85%

The compound of example 22 was prepared analogous to compound of example 8 by hydrolysis of compound of example 21.