HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isocyanato-4-methoxybenzene → (S)-Methyl-2-(6-(4-(3-(4-methoxyphenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isocyanato-4-methoxybenzene | HCID 79443 | — |
| Reactant | (S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731441 | — |
| Product | (S)-Methyl-2-(6-(4-(3-(4-methoxyphenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 67307643 | — |
Reaction Steps
The compound of example 27 was prepared analogous to compound of example 7 by reaction of compound of example 6 with 4-methoxy phenyl isocyanate. The compound of example 27 was used directly without isolation for the preparation of compound of example 28.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-0f7c5c2f3e9d47e0af4520c706f555f0 |
| Source note | uspto-grants-2014_06 |