(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → HCID 67306851, compound

HRID 403719Notes

Reaction equation

HRID 403719 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:34])[NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:25]=[C:24]4[C:20]([CH2:21][N:22]([C@@H:27]([CH:31]([CH3:33])[CH3:32])[C:28]([OH:30])=[O:29])[C:23]4=[O:26])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C1(NC(=O)NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(OC)=O)C4=O)=CC=3)=CC=2)CCCCC1>>[CH:5]1([NH:8][C:9](=[O:34])[NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:25]=[C:24]4[C:20]([CH2:21][N:22]([C@@H:27]([CH:31]([CH3:32])[CH3:33])[C:28]([OH:30])=[O:29])[C:23]4=[O:26])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)[CH2:6][CH2:7][CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 53303121(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acidHCID 131731446HCID 131731446, compound

Product 1

HCID 67306851HCID 67306851, compoundYield 93%

Procedure

The compound of example 34 was prepared analogous to compound of example 8 by hydrolysis of compound of example 33.

Sources & evidence

ORD record
ord-b5f971e0ae794871b8a7fee4225a4e75
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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