3-Isocyanatobenzonitrile → HCID 131731449, compound

HRID 403724Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:26]([C:28]1[CH:29]=[C:30]([N:34]=[C:35]=[O:36])[CH:31]=[CH:32][CH:33]=1)#[N:27]>>[C:26]([C:28]1[CH:29]=[C:30]([NH:34][C:35](=[O:36])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:16]=[C:15]4[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]4=[O:17])=[CH:10][CH:9]=3)=[CH:6][CH:7]=2)[CH:31]=[CH:32][CH:33]=1)#[N:27]

Participants

Reactant 2

HCID 27333153-Isocyanatobenzonitrile

HCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731449HCID 131731449, compound

Procedure

The compound of example 41 was prepared analogous to compound of example 7 by reaction of compound of example 6 with 3-cyanophenyl isocyanate. The compound of example 41 was used directly without isolation for the preparation of compound of example 42.

Sources & evidence

ORD record: ord-4ce503d0851548e8a071298db6c23636
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08748426B2

Reaction notes

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