(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid → (S)-2-(6-(4-(3-(4-Chloro-2-phenoxyphenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(6-(4-(3-(4-Fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid	HCID 53303121	—
Reactant	(S)-Methyl 2-(6-(4-(3-(4-chloro-2-phenoxyphenyl)ureido)phenyl)-1-oxo isoindolin-2-yl)-3-methylbutanoate	HCID 67375923	—
Product	(S)-2-(6-(4-(3-(4-Chloro-2-phenoxyphenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 67307583	82%

The compound of example 44 was prepared analogous to compound of example 8 by hydrolysis of compound of example 43.