5-Chloro-2-phenoxyphenyl isocyanate → HCID 131731450, compound

HRID 403728Notes

Reaction equation

HRID 403728 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Cl:26][C:27]1[CH:28]=[CH:29][C:30]([O:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[C:31]([N:33]=[C:34]=[O:35])[CH:32]=1>>[Cl:26][C:27]1[CH:28]=[CH:29][C:30]([O:36][C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)=[C:31]([NH:33][C:34](=[O:35])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:16]=[C:15]4[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]4=[O:17])=[CH:10][CH:9]=3)=[CH:6][CH:7]=2)[CH:32]=1

Participants

3

Reactant 2

HCID 50863675-Chloro-2-phenoxyphenyl isocyanateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731450HCID 131731450, compound

Procedure

The compound of example 45 was prepared analogous to compound of example 7 by reaction of compound of example 6 with 5-chloro-2-phenoxy phenyl isocyanate.

Sources & evidence

ORD record
ord-4e8e7706a0d64d3c9ac419c9c065fa8f
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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