(S)-2-(6-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(6-(4-(3-(4-Chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(6-(4-(3-(2-Fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 87349957	—
Reactant	(S)-Methyl 2-(6-(4-(3-(4-chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 131731454	—
Product	(S)-2-(6-(4-(3-(4-Chlorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid	HCID 87349671	84%

The compound of example 62 was prepared analogous to compound of example 52 by hydrolysis of compound of example 61.