HRID403753

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=S)Nc4ccccc4F)cc3)cc2C1=O

HCID87349957

未命名化合物

反应SMILES：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=S)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID123559686

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=S)Nc4cccc(C(F)(F)F)c4)cc3)cc2C1=O

HCID87349723

未命名化合物

收率 67%

PROCEDURE

实验过程

The compound of example 76 was prepared analogous to compound of example 52 by hydrolysis of compound of example 75.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-2e96df2062064f6f9fdfa0428e58a289
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08748426B2
来源说明: uspto-grants-2014_06

反应SMILES

FC1C=CC=CC=1NC(=S)NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1.[CH3:35][CH:36]([CH3:72])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][C:46]([C:51]3[CH:56]=[CH:55][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:66]=[CH:65][CH:64]=[C:63]([C:67]([F:70])([F:69])[F:68])[CH:62]=4)=[S:59])=[CH:53][CH:52]=3)=[CH:47][CH:48]=2)[C:43]1=[O:71])[C:38]([O:40]C)=[O:39]>>[CH3:35][CH:36]([CH3:72])[C@H:37]([N:42]1[CH2:50][C:49]2[C:44](=[CH:45][C:46]([C:51]3[CH:52]=[CH:53][C:54]([NH:57][C:58]([NH:60][C:61]4[CH:66]=[CH:65][CH:64]=[C:63]([C:67]([F:69])([F:70])[F:68])[CH:62]=4)=[S:59])=[CH:55][CH:56]=3)=[CH:47][CH:48]=2)[C:43]1=[O:71])[C:38]([OH:40])=[O:39]