HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzenesulfonyl chloride → (S)-Methyl 2-(6-(4-(4-cyanophenylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzenesulfonyl chloride | HCID 39497 | — |
| Reactant | (S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731441 | — |
| Product | (S)-Methyl 2-(6-(4-(4-cyanophenylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731459 | — |
Reaction Steps
The compound of example 79 was prepared analogous to compound of example 77 by reaction of compound of example 6 with 4-cyanobenzene sulfonyl chloride. The compound of example 79 was used directly without isolation for the preparation of compound of example 80.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-f864b0459c28445bad58d581a1bc2331 |
| Source note | uspto-grants-2014_06 |