HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzenesulphonyl chloride → (S)-Methyl 2-(6-(4-(3-chlorophenylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzenesulphonyl chloride | HCID 17909 | — |
| Reactant | (S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731441 | — |
| Product | (S)-Methyl 2-(6-(4-(3-chlorophenylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731462 | — |
Reaction Steps
The compound of example 87 was prepared analogous to compound of example 77 by reaction of compound of example 6 with 3-chlorobenzene sulfonyl chloride. The compound of example 87 was used directly without isolation for the preparation of compound of example 88.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-fdc45701679641d98a0eb23dc5f6cd08 |
| Source note | uspto-grants-2014_06 |