(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(4-(trifluoromethyl)phenylsulfonamido)phenyl)isoindolin-2-yl)butanoate → (S)-3-Methyl-2-(1-oxo-6-(4-(4-(trifluoromethyl)phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid

HRID 403767Notes

Reaction equation

HRID 403767 reaction equation
CC(C)[C@H](N1CC2C(=CC(C3C=CC(NS(C4C=CC=CC=4)(=O)=O)=CC=3)=CC=2)C1=O)C(O)=O.[CH3:34][CH:35]([CH3:71])[C@H:36]([N:41]1[CH2:49][C:48]2[C:43](=[CH:44][C:45]([C:50]3[CH:55]=[CH:54][C:53]([NH:56][S:57]([C:60]4[CH:65]=[CH:64][C:63]([C:66]([F:69])([F:68])[F:67])=[CH:62][CH:61]=4)(=[O:59])=[O:58])=[CH:52][CH:51]=3)=[CH:46][CH:47]=2)[C:42]1=[O:70])[C:37]([O:39]C)=[O:38]>>[CH3:34][CH:35]([CH3:71])[C@H:36]([N:41]1[CH2:49][C:48]2[C:43](=[CH:44][C:45]([C:50]3[CH:51]=[CH:52][C:53]([NH:56][S:57]([C:60]4[CH:65]=[CH:64][C:63]([C:66]([F:69])([F:68])[F:67])=[CH:62][CH:61]=4)(=[O:59])=[O:58])=[CH:54][CH:55]=3)=[CH:46][CH:47]=2)[C:42]1=[O:70])[C:37]([OH:39])=[O:38]

Participants

3

Reactant 2

HCID 53303515(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(4-(trifluoromethyl)phenylsulfonamido)phenyl)isoindolin-2-yl)butanoateHCID 67306729(S)-3-Methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid

Product 1

HCID 67308110(S)-3-Methyl-2-(1-oxo-6-(4-(4-(trifluoromethyl)phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acidYield 93%

Procedure

The compound of example 92 was prepared analogous to compound of example 78 by hydrolysis of compound of example 91.

Sources & evidence

ORD record
ord-4e77a5cadbe840ce820e3fb7c71f7d2b
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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