HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanesulfonyl chloride → (S)-Methyl 3-methyl-2-(6-(4-(1-methylethylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanesulfonyl chloride | HCID 82408 | — |
| Reactant | (S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731441 | — |
| Product | (S)-Methyl 3-methyl-2-(6-(4-(1-methylethylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)butanoate | HCID 131731465 | — |
Reaction Steps
The compound of example 95 was prepared analogous to compound of example 77 by reaction of compound of example 6 with isopropyl sulfonyl chloride. The compound of example 95 was used directly without isolation for the preparation of compound of example 96.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-80c7a8b97d7149ff81b7cdfb928d60b4 |
| Source note | uspto-grants-2014_06 |