(S)-3-Methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid → (S)-3-Methyl-2-(6-(4-(1-methylethylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)butanoic acid

HRID 403771Notes

Reaction equation

HRID 403771 reaction equation
[CH3:1][CH:2]([CH3:33])[C@H:3]([N:7]1[CH2:15][C:14]2[C:9](=[CH:10][C:11]([C:16]3[CH:21]=[CH:20][C:19]([NH:22][S:23]([C:26]4[CH:31]=CC=C[CH:27]=4)(=[O:25])=[O:24])=[CH:18][CH:17]=3)=[CH:12][CH:13]=2)[C:8]1=[O:32])[C:4]([OH:6])=[O:5].CC(C)[C@H](N1CC2C(=CC(C3C=CC(NS(C(C)C)(=O)=O)=CC=3)=CC=2)C1=O)C(OC)=O>>[CH3:1][CH:2]([CH3:33])[C@H:3]([N:7]1[CH2:15][C:14]2[C:9](=[CH:10][C:11]([C:16]3[CH:21]=[CH:20][C:19]([NH:22][S:23]([CH:26]([CH3:31])[CH3:27])(=[O:25])=[O:24])=[CH:18][CH:17]=3)=[CH:12][CH:13]=2)[C:8]1=[O:32])[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 67306729(S)-3-Methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acidHCID 131731465(S)-Methyl 3-methyl-2-(6-(4-(1-methylethylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)butanoate

Product 1

HCID 67307911(S)-3-Methyl-2-(6-(4-(1-methylethylsulfonamido)phenyl)-1-oxoisoindolin-2-yl)butanoic acidYield 49%

Procedure

The compound of example 96 was prepared analogous to compound of example 78 by hydrolysis of compound of example 95.

Sources & evidence

ORD record
ord-98d509ecdda947ae8c8f0789c4013845
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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