(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(6-(4-(4-Methoxybenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acid

HRID 403776Notes

Reaction equation

HRID 403776 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][O:34][C:35]1[CH:67]=[CH:66][C:38]([C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([C:48]3[CH:56]=[C:55]4[C:51]([CH2:52][N:53]([C@@H:58]([CH:63]([CH3:65])[CH3:64])[C:59]([O:61]C)=[O:60])[C:54]4=[O:57])=[CH:50][CH:49]=3)=[CH:44][CH:43]=2)=[O:40])=[CH:37][CH:36]=1>>[CH3:33][O:34][C:35]1[CH:36]=[CH:37][C:38]([C:39]([NH:41][C:42]2[CH:43]=[CH:44][C:45]([C:48]3[CH:56]=[C:55]4[C:51]([CH2:52][N:53]([C@@H:58]([CH:63]([CH3:64])[CH3:65])[C:59]([OH:61])=[O:60])[C:54]4=[O:57])=[CH:50][CH:49]=3)=[CH:46][CH:47]=2)=[O:40])=[CH:66][CH:67]=1

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731467(S)-Methyl 2-(6-(4-(4-methoxybenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67307133(S)-2-(6-(4-(4-Methoxybenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methyl butanoic acidYield 89%

Procedure

The compound of example 104 was prepared analogous to compound of example 98 by hydrolysis of compound of example 103.

Sources & evidence

ORD record
ord-28e7ad0dc8144ef794853672600e5863
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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