(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 53247266, compound

HRID 403787Notes

Reaction equation

HRID 403787 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[C:33]([C:37]1[CH:69]=[CH:68][C:40]([C:41]([NH:43][C:44]2[CH:49]=[CH:48][C:47]([C:50]3[CH:58]=[C:57]4[C:53]([CH2:54][N:55]([C@@H:60]([CH:65]([CH3:67])[CH3:66])[C:61]([O:63]C)=[O:62])[C:56]4=[O:59])=[CH:52][CH:51]=3)=[CH:46][CH:45]=2)=[O:42])=[CH:39][CH:38]=1)([CH3:36])([CH3:35])[CH3:34]>>[C:33]([C:37]1[CH:69]=[CH:68][C:40]([C:41]([NH:43][C:44]2[CH:45]=[CH:46][C:47]([C:50]3[CH:58]=[C:57]4[C:53]([CH2:54][N:55]([C@@H:60]([CH:65]([CH3:66])[CH3:67])[C:61]([OH:63])=[O:62])[C:56]4=[O:59])=[CH:52][CH:51]=3)=[CH:48][CH:49]=2)=[O:42])=[CH:39][CH:38]=1)([CH3:35])([CH3:34])[CH3:36]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731470HCID 131731470, compound

Product 1

HCID 53247266HCID 53247266, compoundYield 87%

Procedure

The compound of example 116 was prepared analogous to compound of example 98 by hydrolysis of compound of example 115.

Sources & evidence

ORD record
ord-983b8123e1f648c7afdffa02c2dac760
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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