(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67306241, compound

HRID 403789Notes

Reaction equation

HRID 403789 reaction equation
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:30]([CH3:32])[CH3:31])[C:27]([OH:29])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C(NC2C=CC(C3C=C4C(CN([C@@H](C(C)C)C(OC)=O)C4=O)=CC=3)=CC=2)=O)CCCCC1>>[CH:2]1([C:1]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:24]=[C:23]4[C:19]([CH2:20][N:21]([C@@H:26]([CH:30]([CH3:32])[CH3:31])[C:27]([OH:29])=[O:28])[C:22]4=[O:25])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)=[O:8])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 53303634HCID 53303634, compound

Product 1

HCID 67306241HCID 67306241, compoundYield 78%

Procedure

The compound of example 118 was prepared analogous to compound of example 98 by hydrolysis of compound of example 117.

Sources & evidence

ORD record
ord-19df4e90708d48d2bd0f3dc6e0b6c599
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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