1,3-Benzodioxole-5-carbonyl chloride → HCID 53303740, compound

HRID 403792Notes

Reaction equation

HRID 403792 reaction equation
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)[C:52]([O:54]C)=[O:53])C3=O)=CC=2)=CC=1.O1C2C=CC(C(Cl)=O)=CC=2OC1>>[O:53]1[C:5]2[CH:6]=[CH:7][C:2]([C:1]([NH:9][C:10]3[CH:11]=[CH:12][C:13]([C:16]4[CH:24]=[C:23]5[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]5=[O:25])=[CH:18][CH:17]=4)=[CH:14][CH:15]=3)=[O:8])=[CH:3][C:4]=2[O:54][CH2:52]1

Participants

4

Reactant 3

HCID 27347491,3-Benzodioxole-5-carbonyl chlorideHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 53303740HCID 53303740, compoundYield 83.7%

Procedure

The compound of example 127 was prepared analogous to compound of example 97 by reaction of compound of example 6 with benzo[d][1,3]dioxole-5-carbonyl chloride.

Sources & evidence

ORD record
ord-48cd6c871d534ef6b7b8ab7469f5c651
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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