(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67306337, compound

HRID 403793Notes

Reaction equation

HRID 403793 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[O:33]1[C:37]2[CH:38]=[CH:39][C:40]([C:42]([NH:44][C:45]3[CH:50]=[CH:49][C:48]([C:51]4[CH:59]=[C:58]5[C:54]([CH2:55][N:56]([C@@H:61]([CH:66]([CH3:68])[CH3:67])[C:62]([O:64]C)=[O:63])[C:57]5=[O:60])=[CH:53][CH:52]=4)=[CH:47][CH:46]=3)=[O:43])=[CH:41][C:36]=2[O:35][CH2:34]1>>[O:33]1[C:37]2[CH:38]=[CH:39][C:40]([C:42]([NH:44][C:45]3[CH:46]=[CH:47][C:48]([C:51]4[CH:59]=[C:58]5[C:54]([CH2:55][N:56]([C@@H:61]([CH:66]([CH3:68])[CH3:67])[C:62]([OH:64])=[O:63])[C:57]5=[O:60])=[CH:53][CH:52]=4)=[CH:49][CH:50]=3)=[O:43])=[CH:41][C:36]=2[O:35][CH2:34]1

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 53303740HCID 53303740, compound

Product 1

HCID 67306337HCID 67306337, compoundYield 64.6%

Procedure

The compound of example 128 was prepared analogous to compound of example 98 by hydrolysis of compound of example 127.

Sources & evidence

ORD record
ord-211ff5f929dc4eacbba4dd75f0c72fb1
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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