(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 70975347, compound

HRID 403795Notes

Reaction equation

HRID 403795 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[Cl:33][C:34]1[CH:66]=[CH:65][CH:64]=[C:63]([Cl:67])[C:35]=1[C:36]([NH:38][C:39]1[CH:44]=[CH:43][C:42]([C:45]2[CH:53]=[C:52]3[C:48]([CH2:49][N:50]([C@@H:55]([CH:60]([CH3:62])[CH3:61])[C:56]([O:58]C)=[O:57])[C:51]3=[O:54])=[CH:47][CH:46]=2)=[CH:41][CH:40]=1)=[O:37]>>[Cl:33][C:34]1[CH:66]=[CH:65][CH:64]=[C:63]([Cl:67])[C:35]=1[C:36]([NH:38][C:39]1[CH:44]=[CH:43][C:42]([C:45]2[CH:53]=[C:52]3[C:48]([CH2:49][N:50]([C@@H:55]([CH:60]([CH3:62])[CH3:61])[C:56]([OH:58])=[O:57])[C:51]3=[O:54])=[CH:47][CH:46]=2)=[CH:41][CH:40]=1)=[O:37]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731473HCID 131731473, compound

Product 1

HCID 70975347HCID 70975347, compoundYield 43%

Procedure

The compound of example 130 was prepared analogous to compound of example 98 by hydrolysis of compound of example 129.

Sources & evidence

ORD record
ord-2084e9e2a2014fc2abc19645869f35c4
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…