(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67305848, compound

HRID 403804Notes

Reaction equation

HRID 403804 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][O:34][C:35]1[CH:36]=[C:37]([CH:65]=[CH:66][C:67]=1[O:68][CH3:69])[C:38]([NH:40][C:41]1[CH:46]=[CH:45][C:44]([C:47]2[CH:55]=[C:54]3[C:50]([CH2:51][N:52]([C@@H:57]([CH:62]([CH3:64])[CH3:63])[C:58]([O:60]C)=[O:59])[C:53]3=[O:56])=[CH:49][CH:48]=2)=[CH:43][CH:42]=1)=[O:39]>>[CH3:33][O:34][C:35]1[CH:36]=[C:37]([CH:65]=[CH:66][C:67]=1[O:68][CH3:69])[C:38]([NH:40][C:41]1[CH:46]=[CH:45][C:44]([C:47]2[CH:55]=[C:54]3[C:50]([CH2:51][N:52]([C@@H:57]([CH:62]([CH3:64])[CH3:63])[C:58]([OH:60])=[O:59])[C:53]3=[O:56])=[CH:49][CH:48]=2)=[CH:43][CH:42]=1)=[O:39]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731476HCID 131731476, compound

Product 1

HCID 67305848HCID 67305848, compoundYield 79%

Procedure

The compound of example 142 was prepared analogous to compound of example 98 by hydrolysis of compound of example 141.

Sources & evidence

ORD record
ord-7bd92bc3be2945a78e5a2a25f3d16047
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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