(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 70975404, compound

HRID 403808Notes

Reaction equation

HRID 403808 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH2:33]([O:35][C:36]1[CH:37]=[C:38]([CH:66]=[C:67]([O:69][CH2:70][CH3:71])[CH:68]=1)[C:39]([NH:41][C:42]1[CH:47]=[CH:46][C:45]([C:48]2[CH:56]=[C:55]3[C:51]([CH2:52][N:53]([C@@H:58]([CH:63]([CH3:65])[CH3:64])[C:59]([O:61]C)=[O:60])[C:54]3=[O:57])=[CH:50][CH:49]=2)=[CH:44][CH:43]=1)=[O:40])[CH3:34]>>[CH2:33]([O:35][C:36]1[CH:37]=[C:38]([CH:66]=[C:67]([O:69][CH2:70][CH3:71])[CH:68]=1)[C:39]([NH:41][C:42]1[CH:47]=[CH:46][C:45]([C:48]2[CH:56]=[C:55]3[C:51]([CH2:52][N:53]([C@@H:58]([CH:63]([CH3:64])[CH3:65])[C:59]([OH:61])=[O:60])[C:54]3=[O:57])=[CH:50][CH:49]=2)=[CH:44][CH:43]=1)=[O:40])[CH3:34]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731477(S)-Methyl 2-(6-(4-(3,5-diethoxybenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 70975404HCID 70975404, compoundYield 82%

Procedure

The compound of example 146 was prepared analogous to compound of example 98 by hydrolysis of compound of example 145.

Sources & evidence

ORD record
ord-1efdb5414e814558b6a7c1710d173fd5
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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