(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67307025, compound

HRID 403812Notes

Reaction equation

HRID 403812 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:72])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56](=[O:70])[C:57]4[CH:62]=[CH:61][C:60]([O:63][C:64]5[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=5)=[CH:59][CH:58]=4)=[CH:51][CH:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:71])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:72])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:50]=[CH:51][C:52]([NH:55][C:56](=[O:70])[C:57]4[CH:62]=[CH:61][C:60]([O:63][C:64]5[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=5)=[CH:59][CH:58]=4)=[CH:53][CH:54]=3)=[CH:45][CH:46]=2)[C:41]1=[O:71])[C:36]([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 53303840HCID 53303840, compound

Product 1

HCID 67307025HCID 67307025, compoundYield 77%

Procedure

The compound of example 150 was prepared analogous to compound of example 98 by hydrolysis of compound of example 149.

Sources & evidence

ORD record
ord-f47fc069123d47bb85d6ea1def459e63
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…