HRID403813

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11075303

2-phenoxybenzoyl Chloride

C13H9ClO2

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O

HCID131731441

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4Oc4ccccc4)cc3)cc2C1=O

HCID131731478

未命名化合物

收率 92%

PROCEDURE

实验过程

The compound of example 151 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 2-phenoxy benzoyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0555843423504804a1168bfb010f3bae
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:31]([CH3:33])[CH3:32])[C:27]([O:29][CH3:30])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[O:59](C1C=CC=CC=1C(Cl)=O)[C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=1>>[CH3:32][CH:31]([CH3:33])[C@H:26]([N:21]1[CH2:20][C:19]2[C:23](=[CH:24][C:16]([C:13]3[CH:12]=[CH:11][C:10]([NH:9][C:1](=[O:8])[C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][C:7]=4[O:59][C:60]4[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=4)=[CH:15][CH:14]=3)=[CH:17][CH:18]=2)[C:22]1=[O:25])[C:27]([O:29][CH3:30])=[O:28]