2,4,6-Trimethylbenzoyl chloride → HCID 131731479, compound

HRID 403815Notes

Reaction equation

HRID 403815 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]([CH:56]([CH3:58])[CH3:57])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[CH3:59][C:60]1[CH:68]=[C:67]([CH3:69])[CH:66]=[C:65]([CH3:70])[C:61]=1[C:62](Cl)=[O:63]>>[CH3:57][CH:56]([CH3:58])[C@H:51]([N:46]1[CH2:45][C:44]2[C:48](=[CH:49][C:41]([C:38]3[CH:37]=[CH:36][C:35]([NH:34][C:62](=[O:63])[C:61]4[C:65]([CH3:70])=[CH:66][C:67]([CH3:69])=[CH:68][C:60]=4[CH3:59])=[CH:40][CH:39]=3)=[CH:42][CH:43]=2)[C:47]1=[O:50])[C:52]([O:54][CH3:55])=[O:53]

Participants

4

Reactant 3

HCID 970382,4,6-Trimethylbenzoyl chlorideHCID 123625862(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731479HCID 131731479, compoundYield 77%

Procedure

The compound of example 153 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 2,4,6-trimethyl benzoyl chloride.

Sources & evidence

ORD record
ord-9d236879724e4b2eb82378242dcf32ab
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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