(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67307567, compound

HRID 403816Notes

Reaction equation

HRID 403816 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:68])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56](=[O:66])[C:57]4[C:62]([CH3:63])=[CH:61][C:60]([CH3:64])=[CH:59][C:58]=4[CH3:65])=[CH:51][CH:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:67])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:68])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:50]=[CH:51][C:52]([NH:55][C:56](=[O:66])[C:57]4[C:58]([CH3:65])=[CH:59][C:60]([CH3:64])=[CH:61][C:62]=4[CH3:63])=[CH:53][CH:54]=3)=[CH:45][CH:46]=2)[C:41]1=[O:67])[C:36]([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731479HCID 131731479, compound

Product 1

HCID 67307567HCID 67307567, compoundYield 81%

Procedure

The compound of example 154 was prepared analogous to compound of example 98 by hydrolysis of compound of example 153.

Sources & evidence

ORD record
ord-fe75fd1e81a54d11b2ff5534b2212b8e
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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