(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 70975315, compound

HRID 403818Notes

Reaction equation

HRID 403818 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][O:34][C:35]1[CH:67]=[C:66]([O:68][CH3:69])[CH:65]=[CH:64][C:36]=1[C:37]([NH:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2[CH:54]=[C:53]3[C:49]([CH2:50][N:51]([C@@H:56]([CH:61]([CH3:63])[CH3:62])[C:57]([O:59]C)=[O:58])[C:52]3=[O:55])=[CH:48][CH:47]=2)=[CH:42][CH:41]=1)=[O:38]>>[CH3:33][O:34][C:35]1[CH:67]=[C:66]([O:68][CH3:69])[CH:65]=[CH:64][C:36]=1[C:37]([NH:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2[CH:54]=[C:53]3[C:49]([CH2:50][N:51]([C@@H:56]([CH:61]([CH3:63])[CH3:62])[C:57]([OH:59])=[O:58])[C:52]3=[O:55])=[CH:48][CH:47]=2)=[CH:42][CH:41]=1)=[O:38]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731480HCID 131731480, compound

Product 1

HCID 70975315HCID 70975315, compoundYield 80%

Procedure

The compound of example 156 was prepared analogous to compound of example 98 by hydrolysis of compound of example 155.

Sources & evidence

ORD record
ord-c709eef97c344dbbbe247ab3b1087334
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…