Hydrazine → 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide

HRID 40382Notes

Reaction equation

HRID 40382 reaction equation
[F:1][C:2]([F:17])([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)[C:3](OC)=[O:4].[NH2:18][NH2:19]>CO>[F:1][C:2]([F:17])([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][CH:11]=[CH:10]2)[C:3]([NH:18][NH2:19])=[O:4]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 58955252Methyl 2,2-difluoro-2-(quinolin-6-yl)acetate

Product 1

HCID 589552502,2-Difluoro-2-(quinolin-6-yl)acetohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution methyl 2,2-difluoro-2-(quinolin-6-yl)acetate (400 mg, 1686 mmol) and anhydrous hydrazine (2153 μl, 67453 mmol) in MeOH (4 mL) was stirred for 1 h at 23° C. The solvents were then removed under reduced pressure to provide product as a white solid. MS (ESI pos. ion) m/z: 238 (MH+). Calc'd exact mass for C11H9F2N3O: 237.

Workup

  1. customThe solvents were then removed under reduced pressure
  2. customto provide product as a white solid

Sources & evidence

ORD record
ord-b594f0bfff614d748aa65917f09145ee
Source dataset
uspto-grants-2013_09
Patent number
US08524900B2

Reaction notes

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