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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 403823Generated: October 27, 2026

4-Fluoro-3-methylbenzoyl chloride → (S)-Methyl 2-(6-(4-(4-fluoro-3-methylbenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

https://huagongshe.com/reaction/403823

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-3-methylbenzoyl chlorideHCID 2774589—
Reactant(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 123625862—
Reactant(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441—
Product(S)-Methyl 2-(6-(4-(4-fluoro-3-methylbenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 13173148385%

Reaction Steps

The compound of example 161 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 4-fluoro-3-methyl benzoyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-499ed3f924b542afa552746e37a671ff
Source noteuspto-grants-2014_06