(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 70975513, compound

HRID 403831Notes

Reaction equation

HRID 403831 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH:33]1([C:39]2[CH:71]=[CH:70][C:42]([C:43]([NH:45][C:46]3[CH:51]=[CH:50][C:49]([C:52]4[CH:60]=[C:59]5[C:55]([CH2:56][N:57]([C@@H:62]([CH:67]([CH3:69])[CH3:68])[C:63]([O:65]C)=[O:64])[C:58]5=[O:61])=[CH:54][CH:53]=4)=[CH:48][CH:47]=3)=[O:44])=[CH:41][CH:40]=2)[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH:33]1([C:39]2[CH:71]=[CH:70][C:42]([C:43]([NH:45][C:46]3[CH:51]=[CH:50][C:49]([C:52]4[CH:60]=[C:59]5[C:55]([CH2:56][N:57]([C@@H:62]([CH:67]([CH3:69])[CH3:68])[C:63]([OH:65])=[O:64])[C:58]5=[O:61])=[CH:54][CH:53]=4)=[CH:48][CH:47]=3)=[O:44])=[CH:41][CH:40]=2)[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]1

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731487HCID 131731487, compound

Product 1

HCID 70975513HCID 70975513, compoundYield 82%

Procedure

The compound of example 174 was prepared analogous to compound of example 98 by hydrolysis of compound of example 173.

Sources & evidence

ORD record
ord-044e39b48fe14fb9b030681879394c5c
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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