(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 53303842, compound

HRID 403833Notes

Reaction equation

HRID 403833 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:73])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56]([C:58]4[CH:67]=[CH:66][C:65]5[C:64]([CH3:69])([CH3:68])[CH2:63][CH2:62][C:61]([CH3:71])([CH3:70])[C:60]=5[CH:59]=4)=[O:57])=[CH:51][CH:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:72])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:73])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:50]=[CH:51][C:52]([NH:55][C:56]([C:58]4[CH:67]=[CH:66][C:65]5[C:64]([CH3:69])([CH3:68])[CH2:63][CH2:62][C:61]([CH3:71])([CH3:70])[C:60]=5[CH:59]=4)=[O:57])=[CH:53][CH:54]=3)=[CH:45][CH:46]=2)[C:41]1=[O:72])[C:36]([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 123143580(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro naphthalene-2-carboxamido)phenyl)isoindolin-2-yl)butanoate

Product 1

HCID 53303842HCID 53303842, compoundYield 77%

Procedure

The compound of example 176 was prepared analogous to compound of example 98 by hydrolysis of compound of example 175.

Sources & evidence

ORD record
ord-5ca3274144694e44a42e5b8715695e23
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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