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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 403839Generated: October 29, 2026

2-Fluoro-3-(trifluoromethyl)benzoyl chloride → (S)-Methyl 2-(6-(4-(2-fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

https://huagongshe.com/reaction/403839

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-3-(trifluoromethyl)benzoyl chlorideHCID 2737559—
Reactant(S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 123625862—
Reactant(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731441—
Product(S)-Methyl 2-(6-(4-(2-fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 13173149132%

Reaction Steps

The compound of example 193 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 2-fluoro-3-trifluoromethyl benzoyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-cd196b4af2434452baa0f9cb7c8c956c
Source noteuspto-grants-2014_06