(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → (S)-2-(6-(4-(2-Fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid

Participants

Role	Name	HCID	Charge
Reactant	(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 53303631	—
Reactant	(S)-Methyl 2-(6-(4-(2-fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate	HCID 131731491	—
Product	(S)-2-(6-(4-(2-Fluoro-3-(trifluoromethyl)benzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid	HCID 67305818	69%

The compound of example 194 was prepared analogous to compound of example 98 by hydrolysis of compound of example 193.