HRID403841

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734709

3-Fluoro-4-(trifluoromethyl)benzoyl chloride

C8H3ClF4O

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O

HCID131731441

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(C(F)(F)F)c(F)c4)cc3)cc2C1=O

HCID131731492

未命名化合物

收率 78%

PROCEDURE

实验过程

The compound of example 195 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 3-fluoro-4-trifluoromethyl benzoyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-54f704a840ea4a88b2a1c09c8a02a78d
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]([CH:56]([CH3:58])[CH3:57])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[F:59][C:60]1[CH:61]=[C:62]([CH:66]=[CH:67][C:68]=1[C:69]([F:72])([F:71])[F:70])[C:63](Cl)=[O:64]>>[F:59][C:60]1[CH:61]=[C:62]([CH:66]=[CH:67][C:68]=1[C:69]([F:70])([F:71])[F:72])[C:63]([NH:34][C:35]1[CH:36]=[CH:37][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C@@H:51]([CH:56]([CH3:58])[CH3:57])[C:52]([O:54][CH3:55])=[O:53])[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:39][CH:40]=1)=[O:64]