HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2-fluorobenzoyl chloride → (S)-Methyl 2-(6-(4-(3-chloro-2-fluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2-fluorobenzoyl chloride | HCID 2773598 | — |
| Reactant | (S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 123625862 | — |
| Reactant | (S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731441 | — |
| Product | (S)-Methyl 2-(6-(4-(3-chloro-2-fluorobenzamido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731495 | 77% |
Reaction Steps
The compound of example 204 was prepared analogous to compound of example 97 by reaction of compound of example 6 with 3-chloro-2-fluoro benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-51f25cbb51e64a7791eb94fed0882190 |
| Source note | uspto-grants-2014_06 |