(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 89154491, compound

HRID 403852Notes

Reaction equation

HRID 403852 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.C[O:34][C:35](=[O:66])[C@@H:36]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56](=[O:64])[C:57]4[CH:62]=[CH:61][CH:60]=[N:59][C:58]=4[Cl:63])=[CH:51][CH:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:65])[CH:37]([CH3:39])[CH3:38]>>[Cl:63][C:58]1[N:59]=[CH:60][CH:61]=[CH:62][C:57]=1[C:56]([NH:55][C:52]1[CH:51]=[CH:50][C:49]([C:44]2[CH:43]=[C:42]3[C:47]([CH2:48][N:40]([C@@H:36]([CH:37]([CH3:39])[CH3:38])[C:35]([OH:66])=[O:34])[C:41]3=[O:65])=[CH:46][CH:45]=2)=[CH:54][CH:53]=1)=[O:64]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 89154516HCID 89154516, compound

Product 1

HCID 89154491HCID 89154491, compoundYield 85%

Procedure

The compound of example 209 was prepared analogous to compound of example 98 by hydrolysis of compound of example 208.

Sources & evidence

ORD record
ord-9989fd5f23544b7e8b25ba4adc96a358
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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